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A new record for transplant age! 73 year old man/leukemia/HSCT

2024-10-16

On September 13, after more than 100 days of careful treatment by doctors of GoBroad Transplantation Center, Mr. Sun (a pseudonym), a patient with acute myeloid leukemia, was successfully discharged from the hospital. At the age of 73, Mr. Sun set a new record for the oldest allogeneic hematopoietic stem cell transplant patient in the transplant team, as well as in the hospital.

 

At the beginning of this year, Mr. Sun always felt foot pain, body weakness, appetite is also much worse. In the following month, Mr. Sun's symptoms worsened, with foot pain that made it difficult to walk, inability to eat, abdominal distension and irritability. Unable to tolerate the discomfort, Mr. Sun decided to go to the hospital for further evaluation. Routine blood and bone marrow tests revealed that Mr. Sun most likely had leukemia.

On May 3, Sun arrived at Beijing GoBroad Boren Hospital accompanied by his family. Although it was a holiday, Mr. Sun went through the admission process smoothly under the coordination of Wu Tong, Director of the Transplant Center.

Leukemia MICM typing is very important, which helps to determine the type of leukemia, formulate the appropriate treatment plan, and monitor the effect of treatment. After further extensive testing, Sun was finally diagnosed with acute myeloid leukemia with bZIP, CEBPA, CSF3R and NRAS mutations. After 3 rounds of chemotherapy, Sun's condition went into complete remission.

 

However, the disease was more cunning than expected, and during the subsequent consolidation phase, Mr. Sun was found to have 0.02% suspicious primitive myeloid cells in MRD during a routine examination. This meant that he had to undergo hematopoietic stem cell transplantation.

Mr. Sun's age was a major hurdle for the transplant. In general, transplantation for elderly patients is more difficult and risky than for normal patients. To ensure the best treatment outcome, the medical team conducted a thorough pre-transplant evaluation and assessment of Sun and carefully designed a reduced-intensity pre-treatment program that best suited his needs.

 

On July 22-23, Mr. Sun was successfully infused with his son's hematopoietic stem cells. 11 days after the transplantation, platelets were viable, and 14 days after the transplantation, neutrophils were viable, and hematopoietic reconstruction was successful. By September, Mr. Sun's condition was stable and he was discharged from the hospital.

Mr. Sun is especially grateful to the hospital and the medical team for their professional treatment and careful care. He said, "It's the right time to come to the hospital!" He is also very grateful to his family for their companionship and support. Since his illness, his family has been with him all the time, from financial support, spiritual encouragement, physical care to the details of his life, they have taken care of Sun without reservation and in every detail, which also inspired his courage and strength to overcome the illness. Sun's wife was a head nurse at the hospital before she retired, with rich medical and nursing experience, and he was able to be discharged from the hospital without her meticulous care. Although he cannot return to his hometown for the time being, Mr. Sun still feels very happy to have crossed the "line between life and death," and he said that what he wants most at the moment is to have a family reunion.

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