Dr. Fan YANG

Dr. Fan YANG

  • Associate Chief Physician
  • Department of Lymphoma & Myeloma, Beijing GoBroad Hospital
Request an Appointment

About the Doctor

Dr. Yang Fan has nearly two decades of clinical and research experience in hematology and is recognized for her expertise in the precision diagnosis and comprehensive management of malignant hematologic diseases, including lymphoma, multiple myeloma, and acute leukemia. She has extensive hands-on experience in CAR-T cell therapy, as well as autologous and allogeneic hematopoietic stem cell transplantation (HSCT), and has managed numerous complex and high-risk cases throughout the full continuum of care.

Dr. Yang’s research focuses on integrated strategies combining CAR-T therapy with HSCT, mechanisms of immune escape in relapsed/refractory hematologic malignancies, post-transplant immune reconstitution and microenvironmental regulation, and predictive modeling for acute and chronic graft-versus-host disease (GVHD). She has led and participated in multiple clinical and translational research projects that have contributed valuable evidence to the advancement of high-level therapeutic strategies in hematologic oncology. Her research has been presented multiple times at major international conferences such as ASH, EHA, EBMT, and APBMT, reflecting her strong academic influence and international perspective in immunotherapy and transplantation for hematologic malignancies.

Areas of Expertise

  • Comprehensive management of lymphoma, multiple myeloma, and leukemia
  • CAR-T cell therapy (patient evaluation, administration, CRS/ICANS management)
  • Autologous and allogeneic HSCT across the full treatment continuum
  • Management of post-transplant complications (GVHD, TMA, VOD, infections, etc.)
  • Personalized immunotherapy and targeted therapy strategies for relapsed/refractory hematologic malignancies
  • Multidisciplinary (MDT) decision-making and integrated care for complex cases

Contact information and location

Whatsapp
+86 15901185120
Address
Block A/B/C,Longwei Square,Jitong East Road,Fengtai District,Beijing,China

Related reading

Efficacy and safety of venetoclax in combination therapy for relapsed acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation

Objective : To evaluate the efficacy of the B-cell lymphoma 2 (BCL2)-inhibitor venetoclax in combination therapy for relapsed acute myeloid leukemia (AML) patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Methods : We retrospectively analyzed 7 adults with relapsed AML who failed at least one prior therapy and were treated with venetoclax in combination with decitabine and/or low-dose cytarabine at the Beijing Boren hospital between March 2019 and March 2020. Four patients (57.1%) had adverse cytogenetic findings. Four patients (57.1%) had undergone a donor lymphocyte infusion (DLI) prior to venetoclax therapy, while four patients (57.1%) had leukemia and failed prior hypomethylating agent (HMA) therapy.

Results : The objective response rate (ORR) was 71.4% (5 patients achieved morphological complete remission with incomplete hematologic recovery, CRi). At the end of the follow-up period, 3/5 cases (60%) in the CRi group achieved minimal residual disease (MRD) negativity by flow cytometry. One patient (14.3%) successfully underwent allo-HSCT. The median follow-up time was 140 (120, 354) d. Among the seven patients, one died of relapse after remission, with an overall survival rate of 85.7% and a disease-free survival rate of 57.1% (4/7). Five of these patients (71.4%) had an identifiable infection, including septicemia (one patient), herpes zoster (two patients), and pneumonia (two patients). One patient had a tumor lysis syndrome.

Conclusion : The venetoclax-based combinations demonstrated efficacy in treating adult patients with AML relapsing after allo-HSCT.

Refer to the original:https://doi.org/10.31547/bct-2020-025

View

We're here for you.

Get in touch.

We're here to make sure you are connected to the right people.

Request an Appointment